A RECEPTOR FOR ANTIBODY ON B LYMPHOCYTES

A Receptor for Antibody on B Lymphocytes

Evidence is presented for the existence on all B lymphocytes, but not on T lymphocytes, of a membrane-associated receptor for antibody. The receptor was detected by a radioautographic technique in which lymphoid cells were incubated with antibody followed by the corresponding radioiodinated antigen. The ease with which antibody eluted during washing indicated that the bond between antibody and ...

612 Antibody Receptor on B Lymphocytes

Ant ibody-ant igen complexes bind to the surface of some mouse lymphocytes (1-2). Recent evidence has suggested tha t this proper ty may be characteris t ic of some nonthymus-der ived "B" lymphocytes: (3), not of thymus-der ived " T " lymphocytes (4). A similar conclusion has been reached independent ly in our laboratory from studies originally designed to examine the relat ionship between anti...

CD20 Antibody Primes B Lymphocytes for Type I Interferon Production

CD20 is a B cell surface marker that is expressed in various stages in B lymphocytes and certain lymphomas. Clinical administration of CD20 antibody, such as rituximab, is used widely to treat human B-cell lymphomas and other diseases. However, CD20 antibody failed to treat systemic lupus erythematosus (SLE or lupus). The reason for the failure is currently unknown. Type I interferons (IFN) are...

The biologic significance of Fc receptor on mouse B-lymphocytes.

Expression and function of a receptor for hyaluronan-mediated motility on normal and malignant B lymphocytes.

Migration through extracellular matrix is fundamental to malignant invasion. A receptor for hyaluronan-mediated motility (RHAMM) has previously been shown to play a fundamental role in locomotion of ras-transformed cells as well as functioning in signal transduction. Expression of RHAMM was characterized on B lymphocytes from normal and malignant lymphoid tissues using multiparameter phenotypic...